HEALTH AND MEDICINE
 
Development of Sterile Insect Technique for Dengue Mosquito Vector, Aedes aegypti Using Gamma Irradiation
SIT
Project Leader:

Glenda B. Obra
Head,  Agriculture Research Section
Atomic Research Division
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Project Staff:

Resilva, Sotero S.
Javier, Abigaile Mia V.
Dimaano, Arvin O.
Isip, Flora C.
Lazo, Dolores M.
Garcia, Ricky E.
Villareal, Robert E. (Contractual)

Objective: To develop the sterile insect technique for Aedes aegypti mosquito using gamma irradiation.
Brief Description:

Dengue, a disease transmitted by mosquitoes of the genus Aedes, affects more than 100 countries in Africa, the Americas, the Eastern Mediterranean, South-east Asia and the Western Pacific. Of these, South-east Asia and the Western Pacific are most seriously affected and it is endemic in the Philippines.

Sterile insect technique (SIT), a species-specific, effective, and environment-friendly method of pest suppression or eradication, has been successfully used against several insect species. SIT involves the rearing, sterilization and release of insects rendered sterile by gamma radiation. This project will explore SIT as an alternative method of control for Aedes aegypti which can be integrated with other methods of control.

Significance/Impact: Currently, the primary method of controlling or preventing dengue virus transmission is to combat the vector mosquitoes (Aedes) using chemical methods. Although there have been some notable success in such methods, control has not been sustainable in the long term due to problems related with insecticide resistance, health and environmental concerns. If A. aegypti can be rendered sterile by gamma radiation without affecting its quality and competitiveness, then releases of sterile insects can be considered as an alternative method of control for this pest which can be integrated with other methods of control. The project will therefore be beneficial to the Filipinos by addressing the dengue problem brought by the mosquito vector.
Target Beneficiaries: Health sector, researchers/scientists.
Project Duration: 2012 to 2015.
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Application of Food Irradiation Technologies for Enhancing Food Safety, Quality and Agricultural Trade

FoodIrrad
Project Leader:

Zenaida M. de Guzman
Head, Biomedical Research Section
Atomic Research Division

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Project Staff:

Abrera, Gina B.                        
Asa, Anie Day DC                       
Asaad, Celia O.                         
Baldos, Davison T.

Cobar, Ma. Lucia
Diano, Gilberto T .
Valdez, Jeff Darren G.
Tolentino,Mitos M.
Objective: To undertake  R&D  studies on food irradiation and to generate public awareness and interest on the commercial application of food irradiation.
Brief Description:

Significant achievement has been generated in the field of food irradiation technology in terms of R & D, regulations and semi-commercial applications on various food products. 

It is the goal of this project to continue demonstrating the effectiveness of radiation technology as applied to various commodities in order to attract potential stakeholders who will pursue future commercialization of the technology. This includes completion of R&D studies on fresh vegetables and fruits, food for calamity victims, brown rice irradiation, a feasibility study on setting up a commercial irradiation facility, and the development of the  Philippine National Standard on Food Irradiation.

Phase 1 involves the completion of a feasibility study of putting up a commercial irradiation facility in collaboration with the Philippine Center for Postharvest Development and Mechanization (PhilMech, Department of Agriculture   and other agencies. A new Code of Practice for Food Irradiation Processing is being  completed  for publication.   The irradiated and non-irradiated packaging materials will be evaluated for physico-chemical properties and stability of food samples.

Phase 2 involves irradiation of fresh fruits and vegetables, food for calamity victims and brown rice for studying shelf life extension. The quality of irradiated and non-irradiated food products after storage will be evaluated in terms of physico-chemical properties, microbiological, sensory and nutritional analysis.

Significance/Impact: Use of food irradiation as a post-harvest technology for modernization of food and agriculture.
Target Beneficiaries: General public
Project Duration: 2014 to 2016
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Enhancing Cytogenetic Biological Dosimetry Capabilities of the Philippines for Nuclear Incident Preparedness
Cytogenetics
Project Leader:

Celia O. Asaad
Senior Science Research Specialist
Biomedical Research Section
Atomic Research Division

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Project Staff:

Caraos, Gloriamaris L.
Robles, Gerardo Jose M.
Cobar, Ma. Lucia
Asa, Anie Day DC.

Diano, Gilbert T.
Objective: To strengthen the capability of the Philippines in biological dosimetry as part of radiological emergency preparedness and for routine monitoring of workers occupationally exposed  to radiation.
Brief Description:

Cytogenetic biological dosimetry is a method which can measure the amount of radiation received by a person who was exposed to a radiation source.

The evaluation resulting from a cytogenetic biodosimetry analysis helps medical doctors and authorities in making informed decisions on the appropriate treatment of persons who were exposed to radiation. Thus, the management of exposed persons depends largely upon the efficiency of the analysis.

This project aims to strengthen the Philippines’ capability to efficiently conduct cytogenetic biodosimetry analysis by establishing  alternative faster techniques, validating reference curves used in measuring the amount of radiation exposure   and improving both the technical expertise and infrastructure involved in performing the analysis.

Significance/Impact: Improved screening and management of persons who were accidentally or occupationally exposed to radiation.
Target Beneficiaries: General public, radiation workers, physicians, regulatory authorities.
Project Duration: 2012 to 2016.
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Development of Novel Biomedical Products Utilizing Gamma and Electron Beam Facility
Novel
Project Leader:

Zenaida M. de Guzman
Head, Biomedical Research Section
Atomic Research Division
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Project Staff:

Asa, Anie Day DC                               
Asaad, Celia O.                                   
Baldos, Davison T.
Robles, Gerardo Jose M.
Tolentino, Mitos M.
Diano, Gilbert T.
Valdez,Jeff Darren G.

Objective: To develop novel biomedical products utilizing irradiation technology.
Brief Description:

The project aims to develop radiation-processed biomedical products which can contribute to the utilization of natural materials like alginate, honey and other honey byproducts, like propolis, which are available in the market.

Developed gamma-sterilized honey alginate wound dressing has been shown to have excellent absorbency, low pH content and the ability to heal faster than commercial dressings. Additional tests will be completed for the stability test of product using a modified packaging material and validation of animal and clinical trials on a pilot-scale.

A mixture of propolis (honey beehive resin material) and alginate in gel and patch forms are also being developed as antiseptic product. These will be sterilized by gamma irradiation and electron beam technology and the effects on the quality of the product will be compared.

Significance/Impact: Promotes the utilization of locally available materials, like honey, propolis and alginate, through the application of irradiation technology.
Target Beneficiaries: General public.
Project Duration: 2012 to 2016.
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